Sep, Vol. A common genetic background has been hypothesised to be responsible for such an association. Human chromosomal region 8q24 has been associated with many types of cancer.
We report a case of intraductal papillary mucinous carcinoma IPMC of the pancreatic intraductal papillary mucinous neoplasm, complicated by pancreaticobiliary maljunction PBM and an aberrant pancreatic duct draining into the stomach. A year-old man with malaise and jaundice was found to have a mass in the pancreatic head at a local hospital. He was clinically diagnosed with IPMC with invasion to the stomach and duodenum after extensive endoscopic and radiological evaluation and a pancreaticoduodenectomy was performed. Histologically, most of the lesion exhibited proliferation of atypical glands, with irregular papillary and villoglandular structures lined by mucinous columnar epithelium, which extended intraepithelially along the dilated pancreatic duct wall. Tumor cells spread into the duodenal wall formed mucous nodules.
The majority of these associations lie at approximately Mb on chromosome 8. We conducted a study in order to examine the association between IPMN and single nucleotide polymorphisms SNPs from the 8q24 region, namely rs, intraductal papillary mucinous neoplasm, rs, rs, previously reported to influence general cancer susceptibility. The study was performed on IPMN cases and controls.
The results were confirmed also when stratified according to any 1st-degree family history of cancer. However, users may print, download, or email articles for individual use. This abstract may be abridged.
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